Lung Cytopathology (Bronchial and Aspiration Cytology)
WEBIn reactive atypia, bronchial epithelial cells form sheets and/or cluster of cells with mildly to moderately enlarged nuclei, vesicular chromatin, single or multiple small nucleoli, abundant cytoplasm, and normal N:C ratio.
Cross-Talk Between Alveolar Macrophages and Lung Epithelial Cells …
WEBOct 15, 2020 · To maintain a proper balance, the lung needs specialized cells that can efficiently initiate and resolve inflammatory responses. Alveolar macrophages (AMs) and lung epithelial cells (ECs) are described in the literature as being the most important cells in the maintenance of lung homeostasis.
Regulation of immune responses by the airway epithelial cell ... - Nature
WEBJan 13, 2021 · The exploration of cell–cell signalling networks using scRNA-seq data from lung tissue across four mammalian species (including humans) showed crosstalk between epithelial cells and...
Bronchial epithelial cells: The key effector cells in the …
WEBWe provide an overview of recent insights into the function of the bronchial epithelium in the pathogenesis of COPD and how this may provide novel therapeutic approaches for a number of chronic lung diseases.
Biology of lung macrophages in health and disease - PMC
WEBSep 9, 2022 · First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches.
The impact of the lung environment on macrophage …
WEBJan 11, 2022 · Here, we discuss recent developments in our understanding of lung macrophage heterogeneity, ontogeny, metabolism and function in the context of health and disease, and highlight core conceptual...
Editorial: Alveolar Macrophages in Lung Inflammation and …
WEBThe functional phenotype of alveolar macrophages is modulated by the unique microenvironment of the lung that includes intimate contact with epithelial cells, high oxygen tension, and exposure to surfactant-rich fluid.
Cooperation between the alveolar epithelium and lung-resident ... - Nature
WEBMay 12, 2021 · Alveolar macrophages are a subset of lung-resident phagocytes, derived from fetal liver monocytes that migrate to the alveolar niche and establish a highly functionalized pool.
Lung macrophages drive mucus production and steroid-resistant ...
WEBJun 7, 2021 · In this study, we have evaluated the steroid sensitivity of purified, patient-derived sputum and alveolar macrophages and used a novel mechanistic cross-talk assay to examine how macrophages and bronchial epithelial cells cross-talk …
Alveolar macrophages and epithelial cells: The art of living …
WEBSep 7, 2021 · In the lung, alveolar macrophages (AMs) are essential for the catabolism of surfactants generated by alveolar epithelial cells type 2 (AT2s). Consequently, absence or malfunction of AMs results in the development of a disease called pulmonary alveolar proteinosis in human and mice (Trapnell et al., 2019).