Viral Respiratory Pathogens and Lung Injury - PMC - National …
WEBMar 31, 2021 · In this review, we discuss the main RNA (orthomyxoviruses, paramyxoviruses, and coronaviruses) and DNA (adenoviruses, herpesviruses, and bocaviruses) viruses with respiratory tropism and their mechanisms of …
The Role of Epithelial Damage in the Pulmonary Immune Response
WEBOct 15, 2021 · We will review how epithelial cells drive inflammation and fibrosis through interactions with immune cells and fibroblasts and explore emerging concepts around the role of epithelial damage and cell death cascades in pulmonary disease.
Regeneration and repair in the healing lung - PMC - National …
WEBJul 6, 2020 · In response to sustained and extensive damage, the lung is healed via a non‐regenerative process resulting in scar tissue which locally stiffens its structure, which over time leads to a serious loss of lung function and to increasing morbidities.
Regulation of immune responses by the airway epithelial cell ... - Nature
WEBJan 13, 2021 · Immune cell interactions at the epithelial surface. scRNA-seq facilitates the mapping of the diverse innate and adaptive immune cell communities of the airway niche at high resolution. Airway...
The induction and consequences of Influenza A virus-induced cell …
WEBSep 25, 2018 · Facts. The mechanism and consequence of IAV-induced cell death are still debatable. IAV can induce cell death through apoptosis, necrosis, necroptosis and possibly pyroptosis. The mechanism and...
Cellular and functional heterogeneity of the airway epithelium …
WEBPulmonary neuroendocrine cells secrete a range of neuropeptides, while tuft cells are thought to secrete IL-25, acetylcholine and eicosanoids, although the exact role of these molecules in a...
Lung repair and regeneration: Advanced models and insights ... - Cell …
WEBMar 15, 2024 · In response to frequent exposure to damaging agents, injury, and disease, the respiratory system has developed many strategies to repair and regenerate its structure and lost cells. The importance of these regenerative abilities has been underscored by the COVID-19 pandemic, which resulted in acute lung injury in millions of individuals worldwide.
Viral Respiratory Pathogens and Lung Injury - PubMed
WEBMar 31, 2021 · In this review, we discuss the main RNA (orthomyxoviruses, paramyxoviruses, and coronaviruses) and DNA (adenoviruses, herpesviruses, and bocaviruses) viruses with respiratory tropism and their mechanisms of …
The Role of Epithelial Damage in the Pulmonary Immune Response
WEBOct 15, 2021 · Specifically, we highlight the role of epithelial-derived damage-associated molecular patterns (DAMPs) and senescence in shaping the immune response and assess their contribution to inflammatory and fibrotic signalling pathways in the lung.
The airway epithelium: an orchestrator of inflammation, a key ...
WEBIntroduction. Asthma is a heterogeneous disease involving diverse underlying pathobiological mechanisms with different clinical manifestations, typically characterised by excessive inflammatory and bronchoconstrictor responses to the environment. Asthma occurs as a result of the interaction between environmental and host factors over time.
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