Machine learning powers discovery of new cryoprotectants for …
WEB4 days ago · Machine learning powers discovery of new cryoprotectants for cold storage. Datasets and data-driven approaches. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-52266-w. Scientists ...
Chemical approaches to cryopreservation - Nature Reviews …
WEBJul 18, 2022 · Cryopreservation of cells and biologics underpins all biomedical research from routine sample storage to emerging cell-based therapies, as well as ensuring cell banks provide authenticated,...
Solving the puzzle of polymers binding to ice for Cryopreservation
WEBMar 15, 2021 · New polymeric cryoprotectants are emerging, alongside the established cryoprotectants, but how exactly they manage to control ice formation and growth is still largely unknown.
Cryopreservation of tissues by slow-freezing using an emerging
WEBJan 2, 2023 · Cryoprotective agents (CPAs) have been developed to prevent physical damage to cells induced by ice crystals formed under extremely low temperature 1. The most commonly used CPAs are glycerol 2...
Synthetic zwitterions as efficient non-permeable cryoprotectants …
WEBOct 28, 2021 · Blending zwitterions, efficient non-cell-permeating cryoprotectants, and cell-permeating cryoprotectants are expected to exert efficient cryopreservation.
Winter is coming: the future of cryopreservation - BMC Biology
WEBMar 24, 2021 · Future research will focus on ever more complex ways to prevent ice formation and mitigate cryoprotectant toxicity; novel cryoprotectants which exert disproportionately large cryoprotective effects compared to their concentration, in silico molecular modelling, and enhanced understanding of the processes that occur during cryopreservation will ...
Chemical approaches to cryopreservation - PMC - National Center …
WEBJul 18, 2022 · Some of these cryopreservation challenges can be mitigated by the addition of permeating and non-permeating cryoprotectants (CPAs), also referred to as penetrating and non-penetrating cryoprotective agents. Permeating cryoprotectants, including DMSO and glycerol, can cross cellular membranes.
Coping with the cold: unveiling cryoprotectants, molecular …
WEBAug 15, 2023 · The deployment of cryoprotectants is a key adaptive strategy that bolsters plant resilience to cold stress and promotes survival in freezing environments. However, the specific physiological and molecular mechanisms underlying these protective effects remain insufficiently understood.
A Review of the Material Characteristics, Antifreeze Mechanisms, …
WEBMay 3, 2021 · In order to restrict osmotic injury and mechanical injury, researchers are committed to developing cryoprotectants (CPAs) for cryopreservation processes. CPAs are a class of agents that can prevent or reduce damage from freezing and/or thawing.
The Effect of Cryoprotectants and Storage Conditions on the ...
WEBMar 12, 2023 · It is demonstrated, that the use of cryoprotectants protects nanoparticles against loss of function and degradation in all storage conditions. Moreover, it is shown that the addition of sucrose enables all nanoparticles to remain stable and maintain their efficacy for up to a month when stored at −80 °C, regardless of cargo or type of ...
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