In The Substance, Qualley takes on the role of Sue, a more youthful clone of Moore's aging actress who is created by an illicit serum. The film features nudity and plenty of hard to watch moments as the two women, who share one consciousness, inject themselves with the film's titular serum.

We felt like we knew each other,” Demi Moore tells PEOPLE of Margaret Qualley, her costar in Coralie Fargeat’s horror movie Demi Moore and Margaret Qualley had a personal connection offscreen long before sharing one onscreen in their new movie The Substance.

The new body-horror movie "The Substance" is a wild time, It also took co-stars Demi Moore and Margaret Qualley way out of their comfort zones.

The actress is seemingly everywhere this year, and in “The Substance,” she delves into an unusually disturbing new role.

"Unfortunately there is no magic boob potion, so we had to glue those on," the actress said of playing her character, Sue, in the body-horror film

Directed and written by Coralie Fargeat, the film follows the story of TV star and aerobics instructor Elisabeth Sparkle (Moore), who is fired from her own show on her 50th birthday by her boss, Dennis Quaid's cartoonishly misogynist TV exec Harvey – a not-even-slightly-subtle iteration of disgraced abuser Harvey Weinstein.

Demi Moore, Margaret Qualley, Dennis Quaid and more stars hit the red carpet for the L.A. premiere of their film, 'The Substance.' See all the photos.

Moore and Qualley give bravura performances, both surely having faced the scrutiny women in Hollywood and the world are under. Moore allows the camera to film closeups of her thighs and the stomach of a woman who has had kids,