The SAC prevents the APC/C from recognising Cyclin B1, the essential anaphase and cytokinesis inhibitor, until all chromosomes are attached to the spindle. Once chromosomes are attached, Cyclin B1 is ...
The protein DOCK 8 involved in tumor progression Among the 52 proteins identified that had changed on the surface of lysosomes in pancreatic cancer cells, one stood out: the protein called "Dedicator ...
Septins are important for cytokinesis, but their exact roles are still obscure. In fission yeast, four septins (Spn1 to Spn4) accumulate at the rim of the division plane as rings. The octameric ...
The effect is small, and it is not clear how the cells are matched for the stage of cytokinesis. This interesting study implicates the direct interaction between two multi-subunit complexes, known as ...
Dedicator of cytokinesis 8 (DOCK8) deficiency is a severe primary immunodeficiency disorder for which allogeneic hematopoietic cell transplantation (HCT) remains the only definitive cure. This study ...
We are also studying the problem of chromosome segregation and cytokinesis in bacteria. A significant theme is our research is the use of cytological methods to visualize the subcellular location of ...
Reduction of chromosomal instability and inflammation is a common aspect of adaptation to aneuploidy
RPE-1 cells adapt to aneuploidy in vitro, a process characterized by reduced CIN and inflammation. This study shows that this ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and ...
Molecular Cancer Research publishes articles featuring novel, basic cancer research discoveries that prioritize broad molecular and cellular processes. Areas of emphasis include cell cycle and ...
Department of Pediatrics, Stanford University, Stanford, California.
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