No. 18 Michigan inflicted a pair of significant blows in the first half against No. 11 USC on Saturday, taking a 14-3 lead into the break behind stingy defense and explosiveness in its run game. Kalel Mullings busted a 53-yard touchdown run on the Wolverines' third possession to open the scoring after the teams traded early punts.

The No. 18 Michigan Wolverines came away with an upset over the No. 11 USC Trojans in Ann Arbor, 27-24. More news: Former Alabama HC Nick Saban Throws Massive Shade at Rival SEC Program

There are highs and lows every week in college football. The winners and losers for Week 4 start with Southern California's loss to Michigan.